Greetings,
First post here, but I wanted to share a bit of workarounds I have found for some issues that don't seem to have been discussed yet.
First, using Wineskin, I have found the game ran more smoothly using the WS9WineCX15.0.1 engine (this is just an older Wine engine, but modified by the folks at Codeweavers with interesting compatibility patches) and checking you used the Mac Drivers instead of X11 in the Screen options.
Second, to be able to use alt+ shortcuts, I had to check the "Option key works as Alt box"
in the Options tab. Thus I am able to use the command key instead - for instance, I hit Command+F4 to save and quit, instead of having to go through the menus.
Hope it helps!
Thank you for the great game. Looking forward to not be terrible at it