With Auto-sort Inventory turned on and 12 inventory slots, when I right-click any item in my inventory, its item category goes to the top as intended. However, the inventory also auto-scrolls to the bottom, putting the very top item out of view. This means that each time I want to compare items in inventory I must examine one, then scroll up, then examine another, scroll up... or at least it would if I had a larger inventory.
It's slightly annoying, so I'll just leave it off for now, since I can always hit "t", scroll to the group in question, and compare them without any issues.